Clinical Research Office. A partnership between Sheffield Teaching Hospitals NHS Foundation Trust and the University of Sheffield

The modulation of macrophage apoptosis during Streptococcus pneumoniae infection by HIV-1

Sheffield Teaching Hospitals R&D ref STH15411

South Yorkshire Research Ethics Committee ref 11/YH/0217

This page contains information about a research study investigating the causes of pneumonia in people with HIV infection.  This study is now closed. The aim of the study was to look at how HIV affects a part of the immune system that is important at the very earliest stages of lung infection. A total of 31 volunteers agreed to take part in the study, the majority of whom were patients attending for HIV care at the Royal Hallamshire Hospital. We are indebted to these volunteers without whom this study would not have been possible.

Please click on the following links for more information:

Background information about the study and what it involves

Bronchoscopy information sheet

Information for HIV clinicians

Study findings


Study Investigator contact details:

Dr Paul Collini
Study Chief Investigator
MRC Clinical Training Fellow, Department of Infection and Immunity, The University of Sheffield Medical School
Honorary Specialist Registrar, Department of Infectious Diseases and Tropical Medicine, Sheffield Teaching Hospitals
Tel: 0114 271 2439
Email p.collini@sheffield.ac.uk
Web page: www.shef.ac.uk/infectionandimmunity/staffprofiles/collini




Professor David Dockrell
Study Co-investigator
Professor of Infectious Diseases, Department of Infection and Immunity, The University of Sheffield Medical School
Honorary Consultant, Department of Infectious Diseases and Tropical Medicine, Sheffield Teaching Hospitals
Email: d.h.dockrell@sheffield.ac.uk
Secretary - Mrs Sue Clary
Tel: 0114 226 8961
Email: s.clary@sheffield.ac.uk
Web page: www.sheffield.ac.uk/infectionandimmunity/staffprofiles/dockrell