Clinical Research Office. A partnership between Sheffield Teaching Hospitals NHS Foundation Trust and the University of Sheffield

Obstetrics, Gynaecology and Neonatology

Click here for the Academic Directorate of Obstetrics, Gynaecology and Neonatology Research Strategy

Key Contacts

Name Role
Dr Stephen Radley Research Lead
Mr Andrea Galimberti Clinical Director
Julie Ward General Manager
Richard Maxted Service Manager
Andy Lowe Group Finance Manager
Richard Sagol Directorate Accountant
Clare Pye
Directorate Research Coordinator
Julie Cook
Directorate Research Coordinator
Angela Pinder
Clinical Research Office Coordinator (Portfolio and Non-Portfolio Studies)
Gaurika Kapoor
Clinical Research Office Coordinator
(Industry-Sponsored Studies)


The Jessop Wing has a national and international reputation in research in women’s health and neonatology with several areas of strength, including gynaecological oncology, benign gynaecology and reproductive medicine, feto-maternal medicine and neonatology, all of which continue to contribute to the overall research portfolio of the Trust.

We have excellent collaboration between investigators in the NHS and the University of Sheffield with considerable dedicated support and infrastructure to allow them to carry out both clinical and basic science studies. The Jessop Wing is the 4th largest obstetric hospital in the country. Our practice in reproductive medicine and IVF is internationally renowned and generates considerable research.

Patient Involvement and Engagment

Sheffield Life Festival - The Big Knit: 100 Hats for 100 Babies

On 19th April 2016, BBC Radio Sheffield hosted an event that brought together knitters and those that prefer to crochet to make 100 hats for 100 babies born within the Jessop Wing. Whilst at the event, attendees talked to Researchers about the amazing research that they do at the Jessop Wing. 

 The Big Knit in 360: 100 Hats for 100 Babies

The Jessop Wing will gratefully receive any baby hats that you make at home. Feel free to use any patterns that you wish, but below are some examples:

 Knitted Baby Hat Patterns

 Crocheted Baby Hat Patterns

We also need knitted baby blankets of any pattern to reach the approximate size of 35cm x 40cm or 14inch x 15 inch. You will need approximately 50g of acrylic double knitting yarn to complete a blanket and we welcome any pattern (knitted not crochet please). Please post or pop in any completed garments to:

Ward Clerk
Neonatal Intensive Care Unit
Level 2
Jessop Wing
Tree Root Walk
Sheffield S10 2SF

Reproductive Health Panel

The Jessop Wing has a number of active public and patient involvement groups covering themes in obstetrics and gynaecolcogy including the new Reproductive Health Research Public Advisory Panel. For more information on how you can get involved, please click here

Research Strategy

The overall Directorate research strategy aims to create an environment that is supporting and encouraging for the conduct of good quality research. Research is an essential element in the delivery of high quality medical care; enhancing patient care & creating an atmosphere of scientific challenge for clinicians, thereby attracting & retaining staff of high calibre.

The Directorate recognises the need to support portfolio studies which will help establish the jessop Wing as a major research centre and attract and retain high calibre clinicians and academics who will continue to build on this. However, we also wish to encourage non-portfolio, pilot and proof of concept studies as part of this process.

The Directorate Research office supports all research from small pilot projects to larger commercial and portfolio studies. The team within the Directorate incorporates administrative staff along with research nurses/midwives in each of the three clinical areas managing a diverse range of studies.

Research Topics and Leaders

Research Topic Leaders
Generic Obstetrics Andrea Galimberti, Saurabh Gandhi, Tom Farrell, Swati Jha, Roobin Jokhi, Dilly Anumba, Andrew Farkas, Remon Keriakos, Diana Fothergill, Priya Madhuvrata, Shehnaaz Jivraj , Fiona Fairlie, Julie Bodle, Karen Selby , TC Li
Feto-maternal Medicine Dilly Anumba, Saurabh Gandhi
Pregnancy Nutrition Tom Farrell, Hany Lashen, Saurabh Gandhi, Helen Baston
Gynae–oncology John Tidy, Alan Gillespie, Julia Palmer, Fiona Kew, Stephen Radley, Allan Pacey
Gynaecology Mary Connor, TC Li, Swati Jha
Reproductive Medicine TC Li, Allan Pacey, Hany Lashen
Urogynaecology Stephen Radley, Andrew Farkas, Swati Jha
ePAQ Stephen Radley, Swati Jha, Mary Connor
Gynaecology – early pregnancy Shehnaaz Jivraj, TC Li, Joanne Fletcher
Neonatology Robert Coombs, Alan Gibson, Simon Clark, Porus Bustani, Helen Dyson, Kirsteen Mackay, Elizabeth Pilling

Topic 1: Obstetrics

Research Direction

Generic Obstetrics – Research in this field deals with the care of women during pregnancy, childbirth and the recuperative period following delivery

Current And Recent Grants

Shenaaz Jivraj, Tom Farrell, Dotty Watkins, Helen Baston, Fiona Fairlie, Roz Haddrill, Moiad Allazam

Important Publications

  • Jivraj S, Makris M, Saravelos S, Li TC. Pregnancy outcome in women with factor V Leiden and recurrent miscarriage. BJOG 2009; 116: 995-998
  • Jivraj S, Rai R, Underwood J, Regan L. Genetic thrombophilic mutations among couples with recurrent miscarriage. Hum Reprod 2006; 21:1161-1165.
  • King M, Wrench I, Galimberti A and Spray R (2009). Introduction of Cell Salvage to a Large Obstetric Unit. Int J Obstet Anaesthesia 18, 111-117
  • Dhulkotia JS, Alazzam M and Galimberti A (2009). Tisseel for management of traumatic postpartum haemorrage. Arch Gynecol Obstet. 279, 437-439
  • Palmer JE, Jivrajj S, Galimberti A and Paterson M (2009). Serous Ovarian Carcinoma in Pregnancy: a case report. BMJ case Reports, doi:10.1136/bcr.04.2009.1809
  • Bonnett T J and Galimberti A (2009). Early onset Obstetric cholestasis and the differential diagnosis of deranged liver function tests in pregnancy. Abstract RCOG annual meeting.
  • Jivraj S, Anstie B, Cheong YC, Fairlie FM, Laird SM, Li TC. Obstetric and neonatal outcome in women with a history of recurrent miscarriage: a cohort study. Hum Reprod 2001; 16:102-106.

Topic 2: Feto-Maternal Medicine

Research Direction

This research team have a good track record in the field of fetal, neonatal and post-mortem imaging as evidenced by numerous peer-reviewed publications in high impact factor journals and their international reputation.

Current And Recent Grants

  • Genisent Medical Technologies USA, £128,633. Cervical impedance spectroscopy in nonpregnant and pregnant women. PI: Dilly Anumba
  • Sheffield Health Consortium Grant £36,000: Improving access to maternity services: understanding why women present late for antenatal booking. Investigators: Dilly Anumba, G Jones and C Mitchell.
  • Aetiology of Gastroschisis: A Prospective Case Control Study to Investigate the Effects of Lifestyle, Dietary and Enviromental Exposures’ funded by the Birth Defects Foundation. PI Dilly Anumba.
  • Percutaneous shunting for Lower Urinary Tract Obstruction (PLUTO)’ funded by Wellbeing. PI Dilly Anumba.

Important Publications

  • Jokhi RP, Ghule VV, Brown BH, Anumba DO. Reproducibility and repeatability of measuring the electrical impedance of the pregnant human cervix-the effect of probe size and applied pressure. Biomedical Engineering Online. 2009 Jun 17;8:10.
  • Anumba DOC, Lincoln K, Robson SC. Predictive value of clinical and laboratory indices at first assessment in women referred with suspected gestational hypertension. Hypertension in Pregnancy, in press.
  • Jokhi RK, Brown BH, Anumba DOC. The role of cervical Electrical Impedance Spectroscopy in the prediction of the course and outcome of induced labour. BMC Pregnancy and Childbirth, in press.
  • Jivraj S, Anumba D. Optimal cut-off point for protein:creatinine ratio. BMJ 19May 2008.
  • Lavanya T, Cohen M, Gandhi SV, Farrell T & Whitby E. A case of Dandy Walker Variant: The importance of a multidisciplinary team approach using complementary techniques to obtain accurate diagnostic information. Br J Radiol, Oct 2008
  • Gandhi SV, Sprigg A, Cohen M, Whitby E, Anumba DOC. Fetal megalourethra associated with hypoplastic left heart and imperforate anus – a previously unreported association? J Clin Dysmorphol. Jan 2008

Topic 3: Pregnancy Nutrition

Research Direction

Research in pregnancy nutrition is largely led by colleagues in the University Unit of Reproductive and Developmental Medicine. Research in this area focusses on the clincial and social factors associated with pregnancy nutrition, including alchohol consumption, weight loss, diabetic management and the success of Healthy Start schemes.

Current And Recent Grants

Medical Research Council: Scoping and Feasibility Preparation for an RCT on post partum weight loss (WeighWell)
Wellcome Trust: Effects of Prenatal Alcohol Consumption and Alcohol Metabolising Genes on Child Growth and Neurodevelopment in ALSPAC

Important Publications

  • Ford FA, Mouratidou T, Wademan SE and Fraser, RB. Effect of the introduction of ‘Healthy Start’ on dietary behaviour during and after pregnancy: early results from the ‘before and after’ Sheffield Study. Br J Nutr 2009; 101: 1828-1836
  • Kernaghan D, Ola B, Fraser RB, Farrell T, Owen P. Fetal size and growth velocity in the prediction of the large for gestational age (LGA) infant in a glucose impaired population. European J Obs Gynae Reprod Med, 2007; 132: 189-192
  • Mukhopadhyay A, Farrell T, Fraser RB, Ola B. Continuous subcutaneous insulin infusion versus intensive conventional insulin therapy in pregnant diabetic women: A systematic review and metaanalysis of randomized, controlled trials. Am J Obstet Gynecol, 2007; 197: 447-456

Topic 4: Gynae-Oncology

Research Direction

Ovarian and testicular function after chemotherapy and radiotherapy.
Impacts of chemo- and radiotherapy on gamete biology.
Quality of life measurement in women with malignant gynaecological disorders.

Current And Recent Grants

  • ‘Impact of treatment for endometrial and vulval cancer on health related quality of life’ funded by Weston Park Hopital Cancer Appeal £45072. Prof Ledger (CI), Georgina Jones, John Tidy.
  • ‘Treatment for endometrial & vulval cancer: Measuring outcome from the patients perspective’ funded by Weston Park Cancer Hosptial £90000. Georgina Jones (PI) Mr John Tidy, Professor William Ledger, Mr Stephen Radley, Dr Simon Pledge, Professor Sean Keogh
  • ‘Immediate and longer term consequences for men who bank sperm prior to cancer treatment’ funded by Cancer Research UK. PI Allan Pacey

Important Publications

  • Kew FM, Galaal F and Manderville H. Patients’ views of follow up after treatment for gynaecological cancer. Journal of Obstetrics and Gynaecology. 2009; 29(2):135–142.
  • Flynn P, Kew F, Kisely S. Interventions for psychosexual dysfunction in women treated for gynaecological malignancy. Cochrane Gynaecological Cancer Group Cochrane Database of Systematic Reviews In press.

Topic 5: Gynaecology

Current And Recent Grants

  • Swati Jha, Research for Patient Benefit, 2011 Impact of Physiotherapy on Sexual function of women with Stress Urinary Incontinence and a comparison of electrical stimulation versus standard physiotherapy: a randomised controlled trial, £202,886.00
  • Outpatient Ebdometrial Ablation Study: identification of factors that predict pain during outpatient treatment’ funded by OGN Small Granst Scheme 2009, £5000 awarded. Mary Connor CI.
  • OPT Trial: A Randomised Controlled Trial of Outpatient Polyp Treatment for Abnormal Uterine Bleeding,’ funded by NIHR HTA Programme grant. Mary Connor PI.

Important Publications

  • Elliott J, Connor ME, & Lashen L. 2003. The value of out patient hysteroscopy in diagnosing endometrial pathology in postmenopausal women with and without hormone replacement therapy. Acta Obstet Gynecol Scand, 82, pp.1112-1119.
  • Vellayan, M., Connor, M.E. & Baxter, A.J., 2006. Initial experiences performing outpatient hysteroscopic sterilisation (EssureTM). Gynecol Surg, 3, pp.303-307

Topic 6: Reproductive Medicine

Research Direction

Main research interests include clinical and pharmaco economic aspects of ART, pregnancy outcome after IVF and clinical research into surgical and medical management of endometriosis, polycystic ovary syndrome and ectopic pregnancy. There are several pharmaceutical company studies involving GnRH antagonists, aromatase inhibitors, progesterone receptor agonists and antagonists, long acting GnRH agonists in gynaecology and IVF and new approaches to ovarian stimulation.

Current And Recent Grants

  • Commercial grant from Ipsen UK Ltd, £210172. ‘An prospective multi centre single arm open label study of the long term use of an LhRH analog(Decapeptyl) in combination with Livial addback therapy in the management of chronic cyclical pelvic pain in pre-menopausal women’ CI: Prof William Ledger CI
  • Commercial grant from Ferring Ltd, £19200. ‘Randomised comparison of recombinant versus urinary derived gonadotropin for controlled ovarian hyperstimulation in GnRH antagonist regulated cycles’. CI: Prof William ledger CI.
  • Akzo Nobel (Organon), £107500. ‘Phase III randomised, double-blind, active-controlled, non-inferiority clinical trial of a single injection of Org 36286 to induce multi-follicular development for controlled ovarian stimulation’. CI: Prof William Ledger
  • Moulton Charitable Foundation Grant. ‘Randomised controlled trial of laparoscopic adhesiolysis for women with chronic pelvic pain’. Prof TC Li CI.
  • Sheffield Teaching Hospitals Chartiable Trust grant. 'Immune factors and the endometrium’. CI: Prof TC Li
  • OGN Small Grants Scheme 2009, £5000. 'A comparative study of women with recurrent implantation failure and recurrent miscarriage’. Investigators: TC Li, Prof Ledger and Carol Coughlan

Important Publications

  • Metwally M, Ong K, Ledger WL & Li TC (2008). Does high body mass index increase the risk of miscarriage after spontaneous and assisted conception? A meta analysis of the evidence. Fertility & Sterility, 90(3), pp.714-726.
  • Waylen A, Metwally M, Jones GL, Wilkinson AJ & Ledger WL (2009). The effect of cigarette smoking upon clinical outcomes of assisted reproduction: a meta-analysis. Human Reproduction 15(1): 31-44
  • Amer SA, Li TC, Metwally M, Emarh M, Ledger WL (2009). Randomized controlled trial comparing laparoscopic ovarian diathermy with clomiphene citrate as a first-line method of ovulation induction in women with polycystic ovary syndrome. Human Reproduction 24: 219-225.
  • Metwally M, Amer S, Li TC & Ledger WL (2009). An RCT of metformin versus orlistat for the management of obese anovulatory women. Human Reproduction, 24(4), pp.966-975.