Clinical Research Office. A partnership between Sheffield Teaching Hospitals NHS Foundation Trust and the University of Sheffield



Our research focuses on identifying new ways to diagnose and prevent dementia.

Many dementia patients are not diagnosed or are diagnosed too late, leading to inappropriate care and ineffective treatments. Accurate diagnosis of the specific type of dementia in terms of the underlying pathology is essential to the development of targeted treatments for patients.

 Our researchers are working collaboratively with bioinformatics     and INSIGNEO to develop new biomarkers to facilitate early and   differential diagnosis.


 Researchers at Sheffield are developing 'Avatar Aid', an 'avatar' which can analyse patient speech patterns to help diagnose people with dementia



Collaboration with neurophysiology has identified an EEG based biomarker of Alzhiemer's disease which could be widely used for early diagnosis.


In addition to improving diagnosis, our dementia research is progressing in the area of prevention.

Through collaborations with radiology, researchers are identifying the imaging features linked with lifestyle factors that exacerbate cognitive decline, e.g. heavy alcohol consumption, obesity, physical inactivity and smoking.


Our team has devised a cognitive training programme which aims to regulate brain connectivity, and has shown significant positive effects in prodromal Alzheimer's disease.


Dr Daniel Blackburn                    Dementia Theme Lead 
 Dr Ronan O'Malley
 Consultant Neurologist



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