Clinical Research Office. A partnership between Sheffield Teaching Hospitals NHS Foundation Trust and the University of Sheffield

Movement Disorders


Movement Disorders at Sheffield Teaching Hospitals covers research in Parkinson’s disease, Huntington’s disease and functional weakness.

"Movement disorders" refers to a group of nervous system (neurological) conditions that cause abnormal increased movements, which may be voluntary or involuntary.

The UV Study

Our clinicians focus on identifying disease-modifying therapies. Currently, within Sheffield we are exploring the efficacy of the drug Ursodeoyxcholic acid (UDCA) in Parkinson’s Disease. It is hoped this medication could work to slow the disease progression in Parkinson’s. The UP study assesses safety and tolerability of UDCA in patients with Parkinson’s disease. It also measures motor impairment to provide insight into the neuroprotective potential through the use of P-MR-Spectroscopy and sensor-based objective quantification of motor impairment.