Clinical Research Office. A partnership between Sheffield Teaching Hospitals NHS Foundation Trust and the University of Sheffield



Our neuroinflammation theme covers research into multiple sclerosis, ataxia and gluten-related neurological diseases.
The Sheffield MS Research Clinic is one of the major UK centres for Phase II, III and IV clinical trials.
 Sheffield leads the UK on the use of autologous haematopoietic   stem-cell transplantation (AHSCT) as a treatment for MS. As MS is   an autoimmune disease, AHSCT therapy aims to reconstitute and reactivate the brain's immune system.

Ataxia is an umbrella term for a group of neurological disorders which affect balance coordination and speech.

The Sheffield Ataxia Centre is one of three Ataxia Centres of Excellence in the UK, caring for over 1700 patients with different types of Ataxia.
  • Work in Sheffield has demonstrated the benefits of a gluten free diet in patients with gluten ataxia.
  • The use of MR spectroscopy as a biomarker and monitoring tool for ataxia is being explored.
Sheffield has led the way internationally in investigating the neurological manifestations of coeliac disease and gluten sensitivity.

 The Sheffield Gluten/Neurology clinic cares for over 900 patients       with neurological dysfunction related to gluten sensitivity.

 Laboratory work in Sheffield has identified a novel transglutaminase (TG6) that may represent a specific target for these patients.

 Professor Basil Sharrack
 Neuroinflammation - MS Theme Lead
 Professor Marios Hadjivassilou
 Neuroinflammation - Non MS Theme Lead
 Dr David Paling
 Consultant Neurologist & Honorary Lecturer
 Dr Priya Shanmugarajah
 Consultant Neurologist


 Dr Siva Nair
 Consultant Neurologist
 Dr Azza Ismail 
Consultant Neurologist