Clinical Research Office. A partnership between Sheffield Teaching Hospitals NHS Foundation Trust and the University of Sheffield

Motor Neuron Disease (MND) is a group of diseases with multiple causes. Thus, tailoring treatments for the different subtypes of MND may result in more effective therapies.

With Genomic Medicine and Bioinformatics, we hope to identify more genetic risk factors to define more categories of MND. We are working to develop physiological and imaging biomarkers for MND, to monitor disease progression and assess response to treatments.
Gene Therapy work at Sheffield has shown exciting translational promise, with pre-clinical work being developed into experimental medicine trials. Our basic science teams have established cellular models of neurodegenerative diseases to research molecular targets for therapy.


Research in the neuromuscular theme also encompasses work into Duchenne Muscular Dystrophy, Hereditary Spastic Paraparesis, and increasingly, Myasthenia Gravis. Sheffield Teaching Hospitals is proud to take part in multi-centre trials across the disease areas.

 Professor Pamela Shaw
 Theme Lead
 Honorary Consultant Neurologist
 Dr Channa Hewamadduma 
 Deputy Theme Lead
 Professor Chris McDermott           
 Consultant Neurologist