Clinical Research Office. A partnership between Sheffield Teaching Hospitals NHS Foundation Trust and the University of Sheffield

OSCCA Staff Profiles

Ian Wrench

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Deputy lead for Research OSCCA

Lead Clinician for Obstetric Anaesthesia 1999 - 2010


Qualifications: MBChB, BmedSci, PhD, FRCA

Other posts (e.g. membership of specialist bodies etc):
  • Audit lead for OSCCA
  • OAA committee member 2013-16
  • Member of the OAA Information for Mothers sub-committee 2013-18
  • Member of OAA surveys sub-committee 2013-18

Brief overview of Research Background/ activity:
  • 3 Years postgraduate laboratory based research for Ph’D
  • One year Research Registrar at Queen’s Medical Centre Nottingham.
  • Several ethically approved projects completed to publication since Consultant Appointment in 1998.
  • Currently local PI for two portfolio studies

Grants/ studies:
  • SALVO – cell salvage in Obstetrics. Part of team who prepared the successful grant application and principal investigator for Sheffield.
  • POISE2 – perioperative aspirin and clonidine and their effects of perioperative cardiovascular events. PI for Sheffield for this multicentre study.
  • BALANCED – RCT of two levels of BIS during surgery – PI for Sheffield for the multinational study.
  • Can changes in the Pleth Variability Index be used to predict significant hypotension during spinal anaesthesia for Caesarean section? Chief Investigator – small grant from OAA

Invited lectures:
  • Yorkshire Society of Obstetric Anaesthesia – Recent developments in obstetric anaesthesia 2017
  • RCA study day – Hull. Supplementary oxygen for rapid sequence induction 2017
  • Results of SALVO (cell salvage and obstetric anaesthesia) - Obstetric Anaesthesia Study day Manchester 2017
  • Enhanced recovery for obstetric surgery
    • Glasgow – Scottish Obstetric Anaesthetists 2017
    • OAA three day course November 2015
    • Obstetric Anaesthesia Study day Manchester 2014
    • ERP learning collaborative 2014 and 15
    • NHS improving quality 2013
  • Physiological changes of pregnancy in relation to anaesthesia – Yorkshire Anaesthetic Society 2016
  • ESRA 2015 – “magic solutions for regional anaesthesia and analgesia” and Con in debate for use of remifentanil and general anaesthesia for caesarean section.
  • Massive haemorrhage in obstetrics - Obstetric Anaesthesia Study day Manchester 2015
  • Side effects of regional anaesthesia and analgesia for Obstetric Anaesthetic Matrix – Chesterfield 2010 and BBraun Sheffield 2012
  • Preoperative assessment (Matrix) Key topics - Sheffield, 2010
  • Cell salvage and Obstetrics – regional meeting Sheffield 2009


 Full list of publications by Ian Wrench