Clinical Research Office. A partnership between Sheffield Teaching Hospitals NHS Foundation Trust and the University of Sheffield

OSCCA Staff Profiles

Matthew Wilson

Email Address:

Current position:
  • Senior Lecturer in Anaesthesia, School of Health and Related Research (ScHARR) University of Sheffield
  • Honorary Consultant in Obstetric Anaesthesia Sheffield Teaching Hospitals NHS Foundation Trust.


Research Background

I was awarded a National Institute of Health Research "Clinician Scientist" Fellowship in the 2011 competition, which currently entirely funds my current post and a research trial allied to the award (RESPITE).   It was one of only 7 granted in England, across all medical disciplines, in that round. I brought the Fellowship to the School of Health and Related Research at Sheffield University, to pursue funded, national, multi-centre research of high quality.  These studies are automatically eligible for adoption to the UK CRN “portfolio”.

Research Grants Currently Held:

  1. RESPITE: NIHR Clinician Scientist Fellowship. A UK randomised controlled trial of intramuscular pethidine vs. PCA Remifentanil in labour. UKCRN 14923 RESPITE. £832,000. Chief Investigator. Recruiting, 400 participants.
  2. SALVO: A UK national trial of intra-operative red cell salvage for Caesarean Section in women at risk of haemorrhage. NIHR, Health Technology Assessment Programme. NIHR Health Technology Assessment 10/57/32 SALVO. £2.2M. Chief Clinical Investigator. Recruiting 3050 participants.  Estimated completion May 2015.
  3. BUMPES: A trial of maternal position in late labour in women with epidural analgesia. NIHR Health Technology Aseesment ProgrammenHTA 08/22/02 BUMPES. £3.3M. Chief Clinical Investigator. Recruitment complete.  3279 participants. Analysed and reporting November 2015.
  4. TOPIC: A randomised controlled trial to investigate the effectiveness of Thoracic epidural and Paravertebral blockade In reducing Chronic post-thoracotomy pain - Feasibility StudyResearch for Patient Benefit Programme (RfPB) UKCRN ID 18096. £177,000. Co-applicant. Recruiting.

National Institute of Health Research Panel experience:

I served a three year term with the NIHR Health Technology Assessment Program "Interventional Procedures Panel". This national body commissions new studies, reviews funding applications and sets NHS clinical research priorities on behalf of the NIHR.  This appointment has given me unique insight into the process of grant application, prioritization funding allocation and governance. 

Projects in progress:

  • I am co-applicant to a commissioned call from Health Technology Assessment for a trial of pre-operative smoking cessation in major thoracic surgery.  This submission was prioritized for a “Full” application and will be deliberated in the coming weeks.
  • I am CI to an application to the Health Services & Delivery Research program for a national evaluation of the adoption of a complex surgical pathway intervention to facilitate “Enhanced Recovery in planned Caesarean Section”.
  • I am CI to a response to a recent HTA commissioned call for an evaluation of the effectiveness of Gabapentin in acute surgical pain.  This “Expression of Interest” is sponsored by ScHARR CTRU. A full application has been requested

Peer Review:

I am a reviewer to several peer review publications for manuscript submissions referred by editors for critical appraisal including:

  • IJOA (see above)
  • British Journal of Anaesthesia
  • British Journal of Obstetrics & Gynaecology. 

Recent Publications:

  1. Introduction of Enhanced Recovery for Elective Caesarean Section enabling next day discharge: a tertiary centre experience. I. J. Wrench. Allison, A. Galimberti,A. S.Radley, M.J. Wilson. Int J Obstet Anesth. 2015 May;24(2):124-30. doi: 0.1016/j.ijoa.2015.01.003. Epub 2015 Jan 14.
  2. Cell salvage for vaginal delivery - is it time we considered it? Wilson MJ, Wrench IJ.  Int J Obstet Anesth. 2015 May;24(2):97-9. doi: 10.1016/j.ijoa.2015.03.002. Epub 2015 Mar 14.
  3.  "Pharmacological Intervention for Retained Placenta. A Meta-Analysis." James M N Duffy, Matthew J A Wilson, Marian Showell, Khalid S Khan Obstet Gynecol. 2015 Mar;125(3):711-8.
  4. What is the Optimal Pharmacological Management of Prolonged Third Stage of Labour? James M N Duffy, Matthew J A Wilson, Marian Showell, Khalid S Khan. BMJ 2014;349:g4778 doi: 10.1136/bmj.g4778 (Published 28 July 2014).
  5. Does current evidence support the use of Intraoperative Cell Salvage (IOCS) in reducing the need for blood transfusion in caesarean section? Sukhjit K. Dhariwal, Khalid S. Khan, Shubha Allard, Matthew Wilson and Philip Moore on behalf of the SALVO study group Current Opinions in Obstetrics & Gynaecology. 2014; 26 (6): 425-30.
  6. Does the introduction of Cell Salvage to an Obstetric Unit Reduce Blood Transfusion Rates? A. Galimberti · I. Wrench · M. Wilson International Journal of Gynecology & Obstetrics 10/2012; 119:S354-S355. DOI:10.1016/S0020-7292(12)60697-3.
  7. Wilson MJA, Moore PAS, Lancashire R, Shennan A, MacArthur C. Long term effects of epidural analgesia in labour; a randomised controlled trial of mobile epidural techniques.  Birth (Issues in Intrapartum Care 2011; 38(2):105-10.
  8. M. J. A. Wilson, C. MacArthur, G. M. Cooper, D. Bick, P. A. S. Moore, A. Shennan on behalf of the COMET Study Group UK.  Epidural analgesia and breastfeeding: a randomised controlled trial of epidural techniques with and without fentanyl and a non-epidural comparison group.  Anaesthesia 2010; 65: 145-153.

Other Roles:

  • Cochrane Collaborator, anaesthesia and reproductive health
  • Deputy Director NIAA Clinical Trials Network working group.
  • TSC Chair governing the PRISM Study, examining the effectiveness of Positive End Expiratory Pressure in the prevention of respiratory complications post-surgery.
  • Trial Steering Committees of multi-centre studies including the “International Surgical Outcomes Study” (ISOS) and the “ANODE” Trial, administered by the NPEU as an independent panel member.
  • I have been appointed to the steering group of the International Collaboration to Harmonise Outcomes for Pre-eclampsia (iHOPE), funded by the NIHR, as a scientific advisor.