Clinical Research Office. A partnership between Sheffield Teaching Hospitals NHS Foundation Trust and the University of Sheffield

The modulation of macrophage apoptosis during Streptococcus pneumoniae infection by HIV-1

Sheffield Teaching Hospitals R&D ref STH15411

South Yorkshire Research Ethics Committee ref 11/YH/0217

This page contains information about a research study investigating the causes of pneumonia in people with HIV infection.  This study is now closed. The aim of the study was to look at how HIV affects a part of the immune system that is important at the very earliest stages of lung infection. A total of 31 volunteers agreed to take part in the study, the majority of whom were patients attending for HIV care at the Royal Hallamshire Hospital. We are indebted to these volunteers without whom this study would not have been possible.

A summary report of the findings can be found in the document below:

STH15411 Lay Summary Report

Further information about the conduct of the study can be found in the documents below:

 Background information about the study and what it involves

 Bronchoscopy information sheet

 Information for HIV clinicians

Study Investigator contact details:

Dr Paul Collini PhD MBChB MRCP BSc DTM&H
Florey Advanced Fellow & Hon Consultant Infectious Diseases
Florey Institute,
Department of Infection, Immunity and Cardiovascular Diseases (IICD),
Room LU108,
University of Sheffield Medical School,
Beech Hill Road, Sheffield S10 2RX
0114 2159522